Coenzyme Q10: its Positive, Negative Effect and Effectiveness

Coenzyme Q10: its Positive, Negative Effect and Effectiveness

Coenzyme Q10 is essential in facilitating the process that provides cells - and therefore, your body - with energy. As we age, however, its levels begin to fall. Exercise can also raise levels of coenzyme Q10.Coenzyme Q10 (coQ10) is a small molecule present in mitochondria, where it helps combine oxygen with "fuel" from carbohydrates and fat to produce energy also known as ubiquinone.

All cells contain within them a system to make energy. Without energy, the cell cannot power its factories. Coenzyme Q10, a vitamin also known as Co-Q10, plays a critical role in the transport of elements into the cell for the manufacturing of energy. Adequate amounts of Co-Q10 are needed for both the making of energy and the "respiration" of the cell.CoQ10 is used by the body to transform food into adenosine triphosphate (ATP), the energy on which the body runs.CoQ10 is found primarily in fish and meat.

Oxidants are destructive waste products generated in cells. They're sort of like things that cause metals to rust. Coenzyme Q10 can neutralize oxidants. CoQ10 levels are reported to decrease with age and to be low in patients with some chronic diseases such as heart conditions, muscular dystrophies, Parkinson's disease, cancer, diabetes, and HIV/AIDS. Some prescription drugs may also lower CoQ10 levels. Coenzyme Q10 (CoQ10) is an electron acceptor bridging mitochondrial complexes and a potent antioxidant that consistently partially recovers the function of dopaminergic neurons.

Coenzyme Q10 (CoQ10) is a substance found in the mitochondria (energy generators) of all the body's cells, especially the heart cells. Arrhythmias more commonly occur when the heart muscle is weak. Research shows that CoQ10 supplementation can benefit people with weakened heart muscle and may help lessen the risk of arrhythmias. Coenzyme Q10, 60-100 mg twice daily, has been shown to lower blood pressure.

Coenzyme Q, a component of the cell necessary for growth and development, is similar to cholesterol, the UCLA biochemists said. Like cholesterol, Coenzyme Q is produced naturally by the body, and cells require it for life. A deficiency of the antioxidant coenzyme Q10 may be associated with chronic conditions including heart disease and high blood pressure. Symptoms of deficiency include gingivitis, and weakened immune function.

Coenzyme Q10 is a nutrient that helps regulate energy production in cells. Some studies have shown reduction in fine wrinkles around the eyes with no side effects. Other studies show that application before sun exposure it protects against sun damage.

Coenzyme Q10, or ubiquinone, is an antioxidant that occurs naturally in the body and is needed for normal cell reactions. This compound has not been studied for its effectiveness in treating Alzheimer’s.

Animal studies have shown that coenzyme Q10 helps the immune system work well and makes the body better able to resist certain infections and types of cancer. In 3 small studies of coenzyme Q10 in breast cancer patients, some patients appeared to be helped by the treatment.

Research at University of Miami has demonstrated a positive result from using a coenzyme Q10 supplement to treat skin cancers. She recommends 200 milligrams every morning because it has a caffeine-like effect. Coenzyme Q10's effects are cumulative and not immediate.

The supplement coenzyme Q10 appears to reduce migraine frequency for some. Patients who consider alternative therapies should consult their physician about the pros and cons and to prevent any drug interactions.

The researchers discovered that some patients with hereditary ataxia (a genetic neurological disorder that affects coordination may have difficulty with balance and also develop seizures, coordination of arms and legs and speech) have a decreased level of coenzyme Q10, or CoQ10, in their muscles. CoQ10, also called ubiquinone, is a vitamin-like substance that plays a key role in the production of energy within cells. It is naturally present in small amounts in various foods.

A clinical trial showed that coQ10 combined with vitamin E could increase energy production in the cardiac and voluntary muscles of people with FA. Idebenone, a synthetic analogue of coQ10, has generated even more excitement because it’s been shown to shrink the enlarged hearts of people with friedreich’s ataxia (FA).

Cardium which contains the most bioavailable form of coenzyme Q10 and also the powerhouse compound, menaquinone-7 (MK-7). A number of published studies indicate that MK-7 can help shuttle calcium from soft tissues like arteries to bones, where it belongs. This is very good news to the 1 in 20 Americans who have heart disease.

Coenzyme (CoQ10), an antioxidant sold as a dietary supplement, is also involved in mitochondrial processes. "Because of these functions” coenzyme Q10 is also a potent antioxidant and its levels are reduced in the mitochondria of Parkinson patients.CoQ10 has attracted attention concerning neuroprotective actions in neurodegenerative disorders linked to mitochondrial defects or oxidative [oxygen-related] stress, such as Huntington's disease and Parkinson's disease.

The normal lower levels of Coenzyme Q10 in older individuals may be a contributing factor in the progression of some diseases of aging. Coenzyme Q10, which appears to reduce cell death by targeting "excitotoxicity" — the increased activation of a specific receptor on the brain cell's surface. In transgenic mice trials conducted by Weill Cornell researchers, low-dose coenzyme Q10 "showed about a 14% slowing of disease progression," Dr. Beal; professor of Neurology and Chairman of Neurology and Neuroscience at Weill Cornell Medical College, in New York said.

Positive drug effects:

Coenzyme Q10 helps protect the heart from the damaging side effects of doxorubicin, a drug used to treat cancer. Beneficial effects shown with the concomitant administration of coenzyme Q10 with simvastatin in the management of atherosclerosis.

Use of statin drugs depletes the ubiquinone (vitamin-like) Coenzyme Q10, also interferes with any function that depends on cholesterol or Coenzyme Q10 (CoQ10) (e.g. sex hormone production, hair growth, sleep, or proper brain and nervous system function. There is a risk heart failure (the heart is a muscle and it cannot work when deprived of coenzyme Q10). So Coenzyme Q10 (CoQ10) is an essential natural compound that can be depleted from the body by statin-type medications. Taking extra CoQ10 may diminish pain and weakness.

Preclinical and clinical studies by Jonsson Comprehensive Cancer Center at University of California, Los Angeles suggested that anthracycline-induced cardiotoxicity can be prevented by administering coenzyme Q10 during cancer chemotherapy that includes drugs such as doxorubicin and daunorubicin. Studies further suggest that coenzyme Q10 does not interfere with the antineoplastic action of anthracyclines and might even enhance their anticancer effects.

The treatment of patients with nutrients such as coenzyme Q10 has shown promise in the prevention and treatment of neuropathy in other diseases and has been suggested as a way to reduce the nerve toxicity of antiviral drug. Coenzyme Q10 increases growth and survival of nerve cells exposed to HIV medications which cause nerve damage, as indicated by Dr. Catherine L. Cherry of the Burnet Institute, Melbourne, Australia ,publisher in this year(2007).

Therapeutic hypothermia can improve survival after cardiopulmonary resuscitation (CPR).Combining CoQ10 with mild hypothermia immediately after CPR appears to improve survival and may improve neurological outcome in survivors; a study suggested at University Hospitals of Leicester, Leicester, United Kingdom.

Negative drug effects (side effects):

Dietary supplements like gingko biloba, ginseng, garlic, vitamin E, fish oil or coenzyme Q10 can also cause blood-thinning (anticoagulant ,blood-thinning medications such as warfarin) effects, and doses aren't carefully studied and controlled like those for medicines. The total anti-clotting effect from taking both at once, or other interactions between drugs and supplements, are what worry experts.

In a study of individuals taking blood pressure medications (including diltiazem, metoprolol, enalapril, and nitrate), CoQ10 supplementation allowed the individuals to take lower dosages of these drugs. This suggests that CoQ10 may enhance the effectiveness of certain blood pressure medications, but more research is needed to verify these results.

CoQ10 supplementation may reduce the heart-related side effects of timolol drops, a beta-blocker medication used to treat glaucoma, without decreasing the effectiveness of the medication.

Other drugs such as fibric acid derivatives for cholesterol (specifically, gemfibrozil), beta-blockers for high blood pressure (such as atenolol, labetolol, metoprolol, and propranolol), and tricyclic antidepressant medications (including amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, and trimipramine) may have possible drug interaction with coenzyme Q10.

Confusion and questionable its effectiveness:

A small dose of the antioxidant coenzyme Q10 appear to increase blood levels of this naturally occurring compound in patients with Parkinson’s disease, but does not improve Parkinson's disease symptoms, according to JAMA/Archives journals of Neurology appear in the July 2007.

A study reported by Pamela Larsen, UCLA researcher who has studied Coenzyme Q for 10 years shown that adult worms on a diet without Coenzyme Q live 60 percent longer than those on a diet rich in the lipid. This research indicates that like cholesterol too much Coenzyme Q for adults can be harmful. Our findings suggest the reason for the shorter life span is that Coenzyme Q causes more oxidative damage than it prevents.

The ACC/AHA publication "Guidelines for the Evaluation and Management of Chronic Heart Failure in the Adult" reviewed the available data. It concluded that until more data are available, nutritional supplements such as coenzyme Q10 cannot be recommended to treat heart failure and for patients with angina.

Coenzyme Q10 has not been carefully tested to see if it is safe and effective. Because coenzyme Q10 is sold as a dietary supplement rather than a drug, it is not regulated by the US Food and Drug Administration (FDA).

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