Lymphocyte or White Blood Cell Count Ratio

Lymphocyte / White Blood Cell Count Ratio can Differentiate Between Glandular Fe

A common blood test that measures a patient's ratio of white blood cell types can help doctors distinguish between tonsillitis and mononucleosis and provide appropriate treatment, British researchers say.


Tonsillitis and mononucleosis are common conditions with similar symptoms, including sore throat, fever, painful swallowing, redness of the throat and tonsils, and white plaque on the tonsils, according to background information in the study.

"The importance of differentiating patients with tonsillitis from those with glandular fever (mononucleosis) is the prevention of spontaneous rupture of the spleen and acute intra-abdominal hemorrhage," both of which are potential complications of mononucleosis, the researchers wrote.

Infectious mononucleosis (also known in North America as mono, the kissing disease, or Pfeiffer's disease, and more commonly known as glandular fever in other English-speaking countries) is a disease seen most commonly in adolescents and young adults.Infectious mononucleosis (often called simply "mono") is a common viral infection that causes fever, sore throat, and enlarged lymph nodes. By adulthood, 90-95% of men and women have been infected. Mono usually occurs in people aged 15-25 years. Mono is highly contagious. Not surprisingly, 1-3% of college students contract mono each year. Infection spreads through exposure to body fluids containing the virus. It is most often transmitted via saliva (hence the name "kissing disease"). However, mono can also be spread through blood and genital secretions.

Currently, an expensive mononucleosis spot test is required to differentiate between the two conditions.Mononucleosis spot test detects the presence of heterophile antibodies . Heterophile antibodies are antibodies that non-specifically react against different proteins and are useful in the diagnosis of infectious mononucleosis.This test may take up to 24 hours to perform.

In this study, the researchers analyzed laboratory test results from 100 patients with bacterial tonsillitis and 120 patients with infectious mononucleosis. They looked at the number of lymphocytes (a type of white blood cell involved in immune response) and overall white blood cell count, and found the lymphocyte/white blood cell count ratio averaged 0.54 in the mononucleosis patients and 0.10 in tonsillitis patients.

The study authors concluded that people with a ratio of higher than 0.35 would be correctly diagnosed with mononucleosis 90 percent of the time and people with a ratio of 0.35 or lower would be correctly diagnosed as not having mononucleosis 100 percent of the time.

"In conclusion, we recommend that the lymphocyte-white blood cell count ratio should be used as an indicator to decide whether mononucleosis spot / monospot / heterophile antibody tests are required," the study authors wrote. "Results from our retrospective pilot study suggest that the lymphocyte-white blood cell count ratio could be quickly available alternative test for the detection of glandular fever (mononucleosis)."

Comments

Post new comment

Similar

Multivitamin : is it Really Benificial for Me?

Multivitamin : is it Really Benificial for Me? Scientists are discovering that vitamins, minerals, amino acids, and plant phytochemicals have powerful impacts on many of the biochemical pathways that go awry in disease processes such as diabetes

New Antifungal Drug : Noxafil (Posaconazole) for Use in Patients Who have Weakened Immune Systems

New Antifungal Drug : Noxafil (Posaconazole) for Use in Patients Who have Weaken Bacteria, viruses and other infectious organisms live everywhere. You can find them in the air; on food, plants and animals; in the soil and in the water; and on just about every other surface —

Prevention / Tips / Healing Of Tailbone / Coccyx Injury (Fracture / Trauma)

Prevention / Tips / Healing Of Tailbone / Coccyx Injury (Fracture / Trauma) Tailbone(or coccyx) trauma is an injury to the small bone at the lower tip of the spine.It is usually injured in a fall onto a hard surface, such as ice or stairs. The pain usually is due to bruising

Comparison Between Concurrent Administration of Both Radiation and Chemotherapy

Comparison Between Concurrent Administration of Both Radiation and Chemotherapy Standard therapies for cancer primarily include surgery, radiation therapy and chemotherapy. Your doctor may also use other treatments — including alcohol injections, electric current therapy or

A New , Cheap Way to Produce Immune System Antibody

A New , Cheap Way to Produce Immune System Antibody to Treat Cancer and Viruses When one or more of these genes or chromosomes are missing or mutated, or if extra chromosomes are present, the proteins may not get made, may be made incorrectly, or too many may be made. Any of

New Effective Treatment of Inflammatory Bowel Disease (IBD)

New Effective Treatment of Inflammatory Bowel Disease (IBD) / Ulcerative Colitis The digestive system is the set of organs that digest food and absorb the important nutrients your body needs to stay healthy and grow. Two of the major parts of the digestive system are the small

Water Filters: Dance Your Way to Bliss

Water Filters: Dance Your Way to Bliss Water is one of the most precious things available on earth. Though it is colorless, it appears to be the most beautiful thing when it flows across mountains, plains and into the sea. Have you ever