Pregnant Women With Sickle Cell Trait (SCT) Need Special Care and Attention Due to Risk of Multiple Births

Pregnant Women With Sickle Cell Trait (Sct) Need Special Care and Attention Due

Sickle cell anemia is an inherited disease that causes abnormal red blood cells. It is a lifelong disease. Sickle cell trait is not the same as sickle cell disease. If your child has sickle cell trait, it means that he or she has one abnormal gene that causes sickle cell disease. For someone to have sickle cell disease, the person needs 2 abnormal sickle cell genes. About 2.5 million Americans have sickle cell trait.


Having sickle cell trait does not cause symptoms or other problems that occur with sickle cell disease. Normal hemoglobin is called hemoglobin A, but people with sickle cell disease have only hemoglobin S, which turns normal, round red blood cells into abnormally curved (sickle) shapes.
Normally, a person inherits two genes (one from each parent) that produce beta-globin, a protein needed to produce normal hemoglobin (hemoglobin A). A person with sickle cell trait inherits one normal beta-globin gene (hemoglobin A) and one defective gene (hemoglobin S).

Sickle-cell anaemia is particularly common among people whose ancestors come from sub-Saharan Africa, India, Saudi Arabia and Mediterranean countries. Migration raised the frequency of the gene in the American continent. In some areas of sub-Saharan Africa, up to 2% of all children are born with the condition. In broad terms, the prevalence of the sickle-cell trait (healthy carriers who have inherited the mutant gene from only one parent) ranges between 10% and 40% across equatorial Africa and decreases to between 1% and 2% on the north African coast and

African-American women with the sickle cell trait are less likely to delivery prematurely and more likely to have multiple births than their counterparts without the sickle cell trait, according to a report in the medical journal Obstetrics & Gynecology.

Women of African-American descent should therefor be offered special screening for blood disorders during pregnancy because "there are clear implications for genetic counseling and screening for urinary tract infections" if the sickle cell trait is detected, Dr. Allison S. Bryant told Reuters Health.

Because of the increased risk of multiple births, she added, physicians should know if a woman is a sickle cell carrier, because early detection of multiple pregnancies is important to ensure good outcomes.

Bryant, from the University of California, San Francisco, and colleagues conducted a study with more than 5,000 African-American women who delivered between 1976 and 2001. Of this group, 6.5 percent carried the sickle cell trait.

Compared with the women without the sickle cell trait, women with the trait were 85 percent less likely to deliver before 32 weeks and 94 percent more likely to be carrying more than one fetus. These relationships were still seen after the effects of assisted reproductive technologies and other influential factors were considered, the report indicates.

The risk of preterm delivery was even lower among women carrying more than one fetus.

There have been other reports of an association between the sickle cell trait and more pregnancies and more live births, Bryant noted.

The sickle cell trait is known to provide a survival advantage in areas were malaria is common, such as Africa. This is because malarial parasite, transmitted to humans by the bite of an infected mosquito, attacks red blood cells, which are less likely to be infected when they have a sickle shape.

Some authors have attributed the features of these pregnancies to the genetic selection of the sickle cell trait -- even in areas where malaria is not a threat. The findings of the current study "may fit into this framework," the researcher concluded.

An another study is to assess the pregnancy outcome among women with sickle cell trait [SCT], and to compare it with a control group of women with normal hemoglobin.The incidence of abortion and neonatal death in previous pregnancies was significantly increased among SCT women. So, pregnant women with SCT need special care and attention during pregnancy, labor, puerperium and surgery. They should be identified early to prevent complications such as anemia, infection and fetal wastage.

Comments

I'm 5 months pregnant and i

I'm 5 months pregnant and i just found out a couple days ago that i have sickle cell trait. i'm not sure if the father has the trait because we do not talk. what are the chance of my child having the disease?

Since you have the trait

Since you have the trait there is a 50% chance that you could pass the gene on to your child who will have the sickle cell trait like yourself. For your child to be full sickle cell the father will have to at least be carrying the trait like you.

I am 19 and have known about

I am 19 and have known about my sickle cell trait since I was about 8-9 years old. Just recently I did some intense research and am finding out my unexplainable pains may be caused by my SCT which will make explaining my pains ALOT easier to my hubby.

I have the trait but it

I have the trait but it doesn't seem to affect me. I'm 30 y/o, rarely get sick and have only had a UTI once in my life. I have no medical issue at all, except for my iron tends to be low, but not at a dangerous level.

im confused..... i just had

im confused..... i just had my second child may 1st and just found out that she has the trait. how is it that my 1st doesnt have it and they never told me about it during either of my pregnancy?! is this trait hard to detect sometimes?!

my daughter just has sickle

my daughter just has sickle cell trait,and I just need answers..where I know what to say,when she starts asking me all these why questions..and how or what age is appropriate to be talking to her about this....because my daughter has been in and out of the hospital since i can remember and now she's 7 almost 8 and I'm not getting anywhere on my research.

i have sickle cell trait, but

i have sickle cell trait, but i never get sick and i am 27 now i think it's depend on different people.

I have the trait, I was told

I have the trait, I was told when I was 22 carrying my first child. I'm now 31 three kids and pain free still. Like the other ladies ive never experienced any pain or discompfort due to being a carrier of this disease. I also think it depends on the indivisual.

i have sickle cell trait, but

i have sickle cell trait, but i'used to have bad joint pains since i was 14,especially on very cold nights at school, not frequent though, but was only diagnosed when i was 27. i'm now 30, and the joint pains are back, not frequent, and mainly on cold nights, i also get frequent uti's that come with bad fevers and bad chest pain. So i think more research needs to be put into sickle cell trait cause carriers get more pain than research claims.

I Agree, since i can

I Agree, since i can remember, I have had problems having sickle cell trait and now suffer from fibromyalgia (due to ca accident), my sickle cell trait has made my situation WORSE! I suffered from circulation problems for as long as I remember (4or 5years old) and have anaemia problems etc... I don't think they look into this very well, as sickle cell trait makes other problems WORSE!

You are such a liar.. I have

You are such a liar.. I have sickle-cell trait and I have more problems than "they" say i should have. I had gal stones, sickling complications, and a whole list of other problems that they sickle cell trait ISNT supposed to have.And i have been having these problems since i was like 15 and im a white girl. Figure that!

which baby will get sickle

which baby will get sickle cell anaemia or crises 100%and what is the axact differnt between crises and anamia.

it's depend because i have 2

it's depend because i have 2 kids and both of them have sickle cell trait.

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