Diabetes Swallowing Difficulties (Dysphagia) With Neurological Disorders Might be Treated by Botulinum Toxin

Diabetes Swallowing Difficulties (Dysphagia) With Neurological Disorders Might

The swallowing tract extends from the mouth to the stomach. The act of swallowing is divided into three phases:


Swallowing problems (dysphagia) can be grouped into two categories:

Oropharyngeal dysphagia - These swallowing problems happen before food reaches the esophagus and may result from neuromuscular disease or obstructions. Patients experience difficulty starting a swallow; food goes down the wrong pipe; or there is choking and coughing.

Esophageal dysphagia - These swallowing problems originate in the esophagus. Food or liquids "stick" in the chest or throat and sometimes come back up.

Swallowing difficulties experienced by some people with nerve damage resulting from diabetes can be relieved by injections of botulinum toxin, better known as Botox, Italian doctors report.

"We believe that botulinum toxin may be a first-line intervention" in such cases, Dr. Damiano Gullo told Reuters Health.

Gullo, from the Garibaldi Hospital in Catania, and his colleagues assessed the safety and efficacy of botulinum toxin injected into the upper sphincter of the esophagus in 12 people with type 2 diabetes who had severe swallowing impairment.

A single injection completely resolved the problem for 10 patients while the other two were significantly improved, the team reports in the medical journal Diabetes Care.

The beneficial effect of the injection appeared within a week in all patients and lasted up to 12 weeks, the results indicate.

By 24 weeks, all the patients had a return of swallowing problems, but with a repeat injection they all had another good improvement. Treatments thereafter were given every 3 to 4 months, depending on the response of each patient.

The report indicates that the treatment was well tolerated, with no relevant side effects.

Botulinum toxin injections "can be performed in an outpatient clinic, needing neither hospitalization nor anesthesia," the investigators point out. "It can be repeated when the symptoms reappear, retains the same efficacy, and requires no specific follow-up."

The team has found the treatment helpful for people with swallowing problems related to other disorders, Dr. Gullo said. "We intend to further investigate the use of botulinum toxin for (swallowing problems) associated with other neurological disorders such as stroke and multiple sclerosis."

It is noted that botulism-causing Clostridium botulinum bacteria and their spores are everywhere. Prevalent in soil and marine sediments worldwide, their spores are often found on the surfaces of fruits and vegetables, and in seafood. The bacteria and spores themselves are harmless; the dangerous substance is the toxin produced by the bacteria when they grow. There are seven varieties of botulinum toxin.

Once in the body, the toxin binds to nerve endings at the point where the nerves join muscles. This prevents the nerves from signaling the muscles to contract. The result is weakness and paralysis that descends from the cranium down, affecting, among other things, the muscles that regulate breathing.This bacterial toxin that can paralyze and kill if consumed in contaminated food is now safely used, in a purified form, as a medicine to control certain conditions marked by involuntary muscle contractions.

Comments

Post new comment

Similar

Obese (Overweight) Aged Persons and Strict Diet and Exercise

Obese (Overweight) Aged Persons May Also Can Improve High Blood Pressure, Sugar As you age, maintaining a healthy weight — or losing weight if you're overweight — may be more difficult. Your metabolism generally slows, meaning that your body burns fewer calories. Calories that

Older Adults with Elevated Levels of Uric Acid

Older Adults with Elevated Levels of Uric Acid are more Likely to have Below-Ave Uric acid is the end product of purine metabolism (purines are building blocks of RNA and DNA). Most uric acid produced in the body is excreted by the kidneys. An overproduction of uric acid occurs

Prevent The Risk of Pneumonia Deaths with Influenza Vaccine; Even Benefits for Individuals 65 Years Or Older

Prevent The Risk of Pneumonia Deaths with Influenza Vaccine; Even Benefits for I Many people contract pneumonia while staying in a hospital for other conditions. This tends to be more serious because the patient's immune system is often impaired due to the condition that

Erectile Dysfunction (Impotence) for Male Aging Might Get Remission Naturally

Erectile Dysfunction (Impotence) for Male Aging Might Get Remission Naturally As you know, your body changes as you age, and these changes can affect your sexual relationships and your ability to maintain intimacy with your partner. Although your body's physical changes are

Older Women Should Evaluate Kidney Function if They Determine The Risk of Hip Fracture

Older Women Should Evaluate Kidney Function if They Determine The Risk of Hip Fr "More than 300, 000 people in the United States over age 65 will fracture a hip this year, says Jay S. Magaziner, Ph.D., professor and director of the division of gerontology, Department of

Heart Bypass Surgery May Increase Bone Fracture / Osteoporosis Risk

Heart Bypass Surgery May Increase Bone Fracture / Osteoporosis Risk When one or more of the coronary arteries becomes partially or totally blocked, the heart does not get an adequate blood supply. This is called ischemic heart disease or coronary artery disease (CAD

Antiepileptic Drug: Zonegran (Zonisamide) Might Be an Alternative for Patients

Antiepileptic Drug: Zonegran (Zonisamide) Might Be an Alternative for Patients w Parkinson's disease results when nerve cells in a certain part of the brain die or stop working properly. These cells stop producing an important brain chemical called dopamine. Dopamine normally