Reason to Quit Smoking: Pharmacological Aspect

Reason to Quit Smoking: Pharmacological Aspect

Nicotine appears to be the only pharmacologically active substance in tobacco smoke, apart from carcinogenic tars and carbon monoxide.


EFFECTS ON THE CENTRAL NERVOUS SYSTEM:

The central effect of nicotine is complex and cannot be summed up overall simply in terms of stimulation or inhibition. At the cellular level, nicotine cause neuronal excitation by opening ion channels, exactly as it does in autonomic ganglia and the neuromuscular synapse. It is possible that the overall effect of nicotine effects a balance between activation of nicotine acetylcholine receptors, causing neuronal excitation and desensitization, causing synaptic block. At the spinal level, an inhibition of spinal reflexes occurs and this produces skeletal muscle relaxation.

PERIPHERAL EFFECTS:

The peripheral effects of small doses of nicotine result from stimulation of autonomic ganglia and of peripheral sensory receptor, mainly in the heart and lungs. Stimulation of these receptors elicits various autonomic reflex responses, causing tachycardia, increased cardiac output and increased arterial pressure, reduction of gastrointestinal motility and swearing.

PHARMACOK1NETIC ASPECTS:

An .average cigarette contains about 0.8 g of tobacco and 9-17 mg of nicotine, of which about 10% is normally absorbed by the smoker. This fraction varies greatly with the habits of the smoker and the type of cigarette. Nicotine is the only pharmacologically active constituents of tobacco smoke that is present in sufficient quantity to produce systemic effects. The amount of nicotine absorbed from an average cigarette is about 1.5mg which causes the plasma nicotine concentration to reach 130-200 nmol/lit (20-30 ng/ml).

HARMFUL EFFECTS OF SMOKING:

CONCLUSION:

Smoking is a bad habit and causing for various types of diseases. So, we should avoid this habit as soon as possible for our freshness. It is not only the responsibility of government but also responsibility for all to take necessary measures against this habit. So don’t leave it for tomorrow, keep your societies free from smoking for healthy & diseased free life for our next generation.

Comments

Post new comment

Similar

New Paperback ‘How to STOP SMOKING FOR GOOD in 5 Days’

New Paperback ‘How to STOP SMOKING FOR GOOD in 5 Days’ Winnipeg, Canada November 08, 2006. If you’re among the 70% of smokers who would love to quit smoking, if only you knew how, the new paperback, “How to STOP SMOKING FOR GOOD in 5 Days”, could be just

Analogous of Psychoactive Plant Drug Cannabis / Marijuana Might be Used for Stomach & Colon Ache

Analogous of Psychoactive Plant Drug Cannabis / Marijuana Might be Used for Stom The psychoactive drug cannabis is known by many nicknames (some pertaining to certain preparations.) It is produced from parts of the Cannabis sativa plant, primarily the cured flowers and gathered

Prescription Only Medicine(POM) / Legend Drugs / Rx-Only Drugs /Prescription Drugs-Abuse Still High

Prescription Only Medicine(Pom) / Legend Drugs / Rx-Only Drugs /Prescription Dru When prescription drugs are taken the right way, they are safe and there is little chance of addiction. Drug abuse is the use of illicit drugs or the abuse of prescription or over-the-counter drugs

Cause of Nicotine Addiction: Same Enzymatic Change Shown in Cocaine and Heroin

Cause of Nicotine Addiction: Same Enzymatic Change Shown in Cocaine And Heroin Cigarette smoking remains the leading cause of death and illness among Americans. Every year, roughly 430,000 Americans die from illnesses caused by tobacco use, accounting for one fifth of all

A Single Alcoholic Beverage Daily May Increase Breast Cancer Risk

A Single Alcoholic Beverage Daily May Increase Breast Cancer Risk Human existence is characterized by behaviour patterns—what people do to meet their biological, psychological, and social needs. These patterns may include certain ways of preparing and consuming

Smoker's Diet May Help Quit Smoking by Worsening Taste Sensory

Smoker's Diet May Help Quit Smoking by Worsening Taste Sensory The Pan American Health Organization is involved in tobacco control activities because tobacco has been defined as the number one preventable disease in the Region, causing more deaths than AIDS,

New Cause of Alcohol Dependence /Craving in Our Body

New Cause of Alcohol Dependence /Craving in Our Body Public health problems associated with alcohol consumption have reached alarming proportions, and alcohol has become one of the most important risks to health globally.In 2000 alcohol use was